Saffron
Crocus sativus
B Limited clinical evidenceThe world's most expensive spice. Meta-analyses found 30 mg of saffron extract daily helped mild-to-moderate depression symptoms.
Image: Herbadex Botanik Stüdyosu · Özel Üretim
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At a glance
Saffron is the dried red stigmas of the Crocus sativus flower and contains crocin and safranal. Meta-analyses of small and medium trials suggest 30 mg of saffron extract daily may reduce symptoms of mild-to-moderate depression and anxiety and ease premenstrual syndrome (PMS). Most studies come from one country.
Updated: October 15, 2026
ℹ Compiled from standard pharmacognosy references and clinical literature summaries where no formal EMA monograph exists.
What is it used for?
B Limited clinical evidence
Limited clinical evidence: Supported by small-scale human clinical studies, though sample size and study quality are limited.
How do we rate evidence levels? →Clinical studies suggest 30 mg of saffron extract daily may reduce mild-to-moderate depression and anxiety symptoms. [1]
B Limited clinical evidence
Limited clinical evidence: Supported by small-scale human clinical studies, though sample size and study quality are limited.
How do we rate evidence levels? →Small studies reported eased premenstrual syndrome (PMS) symptoms. [1]
How is it used?
Safety & interactions
Minimum age: 18 years
- Depression needs medical diagnosis and care; never stop antidepressants on your own.
- 5 g or more of saffron a day is toxic; 10–20 g can be fatal.
- In pregnancy, use only food amounts: high doses may trigger uterine contractions.
- Fakes (safflower, dyed corn silk) are very common.
Drug interactions
| Medicine / substance | Effect | Severity |
|---|---|---|
| Antidepressants | Possible added effect; ask a doctor before combining. [2] | Moderate |
| Blood pressure medicines and anticoagulants | High doses may lower blood pressure and increase bleeding. [2] | Minor |
Side effects
- Dry mouth, nausea, headache
- At high doses: bleeding, vomiting, yellowish discolouration
⚕ When to see a doctor
- If high fever, shortness of breath or purulent/bloody phlegm develops
- If symptoms do not improve within 1–2 weeks or worsen
- If severe abdominal pain, jaundice, rash or allergic reaction occurs
Did you know?
About 150,000 flowers are hand-picked for 1 kg of saffron; the Turkish town of Safranbolu is named after it. [1]
Frequently asked questions
Does saffron help depression?
Clinical studies saw benefit for mild-to-moderate symptoms; medical follow-up is needed.
How can I tell real saffron?
Real saffron slowly tints water yellow and the threads keep their colour; fakes colour water fast.
Can I use saffron in pregnancy?
Only a few threads in food.
Sources
- WHO Monographs on Selected Medicinal Plants (Volumes 1–4)World Health Organization · 2009
- Herbs at a Glance: Evidence-Based Fact Sheets on Botanical ProductsNIH NCCIH · 2024
Cite This Page
Saffron (Crocus sativus). Herbadex — Doğal Şifa Rehberi (2026). https://herbadex.com/en/herb/saffron/
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